College football picks schedule Predictions against the spread odds for top 25 games today in Week 1 against the spread odds for top 25 games today
The first week of the 2021 college football season is officially underway, against the spread odds for top 25 games today and while games were played over the last three days, Saturday’s slate is absolutely loaded. Not only is there a rare top-five matchup in Week 1, there’s four other games being contested between top 25 teams that will undoubtedly shake up the college football rankings when they are released on Tuesday.
No. 5 Georgia vs. No. 3 Clemson in Charlotte is clearly the game of the day, but No. 1 Alabama may have its hands full with No. 14 Miami in Atlanta. No. 12 Wisconsin hosts No. 19 Penn State in one of the premier Big Ten showdowns of the season, while No. 17 Indiana invades No. 18 Iowa in another and No. 21 Texas welcomes No. 23 Louisiana in a tough nonconference showdown.
While winning is all that matters for the standings, we care about whether these teams will cover their spreads. Be sure to stick with CBS Sports throughout the day for college football coverage from the opening kickoff on Saturday to the final whistle. Let’s take a look at our expert picks for the first full Saturday of the season.